Photochemistry of a water-soluble coumarin-based photoswitch
The same chromophore we used as photocages turned out to be a photoswitch as well!
The Photoresponsive Molecular Tools Research Group led by Márton Bojtár is a subgroup of the Chemical Biology Research Group (Kele Lab) at the HUN-REN Research Centre for Natural Sciences in Budapest, Hungary.
The main focus of our research is the development of small molecules capable of various functions, mostly in biological systems by the action of light irradiation.
Synthesis of new photocages and other photoresponsive small molecules Chemical biology with light as a trigger Photoactivated drugs Combination of light & bioorthogonal chemistry The same chromophore we used as photocages turned out to be a photoswitch as well!
The story of how we converted rhodamine dyes to photocages & used them in photoactivated chemotherapy is out in JACS!
Light & bioorthogonal chemistry combined - improving the spatiotemporal precision of targeted therapies. Our Minireview is out in Angewandte!